when looking at data obtained from studies with living zithromax side effects kidney mammalian cells, it appears reasonable to assume that dequalinium molecules could be pulled into the mitochondrial matrix in response to the high mitochondrial membrane potential as demonstrated in , which in zithromax side effects kidney turn might lead to the destabilization of the dqasomepdna complex however, the first detailed study, which demonstrated the selective dna release from dqaplexes, was performed using membrane mimicking liposomes fig zithromax side effects kidney as a model for the zithromax side effects kidney intracellular release of dna from dqasomes, the capacity of anionic zithromax side effects kidney liposomes to displace the dna from its cationic carrier was zithromax side effects kidney studied the association of dna with the cationic carrier was assessed by employing sybr green i the fluorescence signal of this dye is greatly enhanced when bound to dna nonbinding results in loss of fluorescence it can be clearly seen that in the vicinity of a charge ratio, dqasomes do not zithromax side effects kidney release any dna in the presence of cytoplasmic membrane mimicking zithromax side effects kidney liposomes dqasomes s � � o � u a � � � cpm imm ��� zithromax side effects kidney anionic liposomes i � � time [sec] fig effect of anionic liposomes on dna release zithromax side effects kidney from dqasomepdna complexes dna was preincubated with sybr until stabilization of the signal, followed by zithromax side effects kidney adding indicated by arrow the zithromax side effects kidney minimal amount of dqasomes necessary zithromax side effects kidney to decrease the signal to background level anionic liposomes were then injected arrow at an zithromax side effects kidney anionic to cationic charge ratio zithromax side effects kidney as shown the displacement of dna from its carrier is indicated by the increase of the fluorescence signal cpm, cytoplasma membrane like liposomes imm, inner mitochondrial membrane like liposomes omm, outer mitochondrial membrane like liposomes cpm, not even at a fold zithromax side effects kidney excess of anionic charge however, with a similar charge excess of anionic liposomes to cationic zithromax side effects kidney dqasomes, and respectively, inner and outer mitochondrial membrane mimicking liposomes imm and omm, respectively are able to displace up to of the dna from its dqasomal carrier in agreement with these data, it was found that for the complete liberation of dna from dna dqasome zithromax side effects kidney complex, a fourfold excess of dicetylphosphate and an eightfold excess zithromax side effects kidney of phosphatidylserine, respectively, are necessary the finding that cpm liposomes, at an anionic to cationic charge ratio of , displace up to of the dna from lipofectin, which was used as zithromax side effects kidney a control, do not liberate any dna from dqasomes even at zithromax side effects kidney a slight excess of anionic charge, leads to the conclusion that besides the charge ratio, other factors may play an zithromax side effects kidney important role in the mechanism of dna release from lipiddna complexes this conclusion is being zithromax side effects kidney further supported by xu and szokas observation that ionic water soluble molecules such as atp, trna, dna, polyglutamic acid, spermidine zithromax side effects kidney and histone do not displace dna from the cationic lipiddna complex, even at a fold charge excess � in their what natural herb can replace dilantin model for the postendocytotic release zithromax side effects kidney of dna from cationic carriers, they assume the formation of a charge neutral ion pair between cationic and anionic lipid, zithromax side effects kidney which ultimately results in the displacement of the dna from the cationic lipid and the release of dna into cytoplasm liposomedna liposome ?